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Genetic Testing

There is much buzz these days about genetic testing and its’ promise to provide answers for the many complex and chronic illnesses that are often difficult to diagnose and tend to respond poorly to care.

Genetic testing can be profoundly useful as a clinical tool, given certain caveats. These tests do give us detailed information about our genetic makeup, including variants in a gene (single nucleotide polymorphisms – SNPs). The outcome of SNPs can be detrimental or beneficial.

Genotype – Your Genetic Inheritance
The sum of an individuals’ genetic makeup is their genotype. A given gene translates to an enzyme that controls a given body function. For instance, BCO1 is a gene encoding the enzyme that converts beta-carotene from vegetables into the essential nutrient vitamin A.

Phenotype
How the genotype is expressed in a person is their phenotype.
As an example of this, people who have variants – SNPs – in the BCO1 gene will tend to have a chronic deficiency of vitamin A unless they eat a lot of foods that are direct sources of the vitamin from animal fats. The deficiency itself could result in night blindness and other eye disorders, skin, hair, and nail conditions, impaired resistance to infections, hormonal deficiencies that include the thyroid, increased risk for birth defects, and an increased tendency to sinus, lung, and intestinal disorders. It is common for the underlying vitamin A deficiency to be unrecognized and the various conditions associated with it to be treated independently and often with drugs.

Epigenetics
All of the external modifiers – environment, stress, diet – that influence the genotype and determine the resultant phenotype are the epigenetic factors/variables. Clinical nutrition, for instance, can be used as an epigenetic variable to modify the phenotype.

An example here is the ALDH gene-enzyme which breaks down aldehydes. It is very common for people to have SNPs that limit this enzyme and the result is reacting to aldehyde exposure. Aldehyde sensitivity will show up as headaches, foggy-headedness, severe fatigue, and muscle aching when exposed to aldehydes from colognes, perfumes, air fresheners, formaldehyde in carpets, furniture, and drapes. Symptoms are also be triggered by fermented foods and drinks (wine, pickles, vinegar) and by mold.

For people with low ALDH because of their genetic predisposition, supplementing the essential trace mineral molybdenum which promotes the enzyme can be life-changing!

Reading The Results of Genetic Testing
Caveat emptor! (buyer beware) Most services that interpret the results of genetic testing are misleading and superficial. Consult with a doctor/nurse/counselor certified in the Opus23 database – it is the most sophisticated database for genetic curation currently.

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Dr. Mark Force

Practice And Mission These experiences and practicing since 1984 have helped me be a catalyst for helping people heal from chronic and complex illnesses that commonly get dropped through the cracks. It’s an honor to be present to people healing; I love the work and study associated with it. There have been many gifted mentors over the years who have shared their knowledge - Lance West, DC, Harry Eidenier, PhD, David Walther, DC, and George Goodheart, DC - and I am extremely grateful to perpetuate their work and vision through practice, teaching, mentoring, writing, and research. My mission now is to turn the knowledge base I've gained from mentors and practice into books and courses for people to practice selfcare and doctors to incorporate more natural healthcare into their practices.

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